The game, slated to kick off at 08.15pm, brings together teams that met in the final of the 2007’s edition in which Yanga emerged victorious and lifted the trophy.
Yanga head coach Hans van der Pluijm has asked his players to be careful throughout.
He said he will deploy many midfielders with a view to foil Mtibwa midfielders.
“It will be a tough and entertaining game," he said.
"Mtibwa Sugar is the best team in this event, I know that."
He stopped short of disclosing his team’s formation for the game, which will see the winner register seven points and enjoy the Group B’s driver’s seat.
“I can not disclose my plans. My players are in great shape and I can change the formation depending on my opponents’ game,” the Netherlands tactician said.
Mtibwa Sugar head coach Mecky Mexime said he does not fear the game despite playing a tougher opponent.
"We will foil crosses from either flank. We won’t give Yanga strikers, Donald Ngoma and Amissi Tambwe, space," Mexime said.
"I have informed my players to opt for a careful approach. We won’t have room for mistakes."
Mtibwa and Yanga have four points apiece from a win and a draw in their respective two games played earlier.
The game will be preceded by the match pitting Azam FC against Mafunzo.
Mafunzo have already been knocked out of the tournament after conceding losses in their first two games.
The second round of the event is expected to come to an end tomorrow, in which Zanzibar’s Jamhuri will play Uganda’s URA whereas Simba will meet Zanzibar’s JKU.