The visitors have to come out victorious over the well-drilled Egyptian side, given the two clubs settled for a 0-0 draw in the stage's first tie played at Azam Complex in Dar es Salaam.
The Tanzanian side is to bank on newly signed attackers, Zambian Rodgers Kola and Congolese Idris Mbombo, to get the better of Pyramids FC.
Mbombo could have scored a crucial goal for Azam FC in the first leg clash, in which his effort from close range was cleared by Pyramids keeper.
Azam FC, in the tournament previous round, saw off Somalia outfit, Horseed FC, beating the latter in both first and return legs.
The first leg tie, played at the Azam Complex on September 11, had Azam FC notching a 1-0 victory over Horseed FC, midfielder Ismail Aziz scored the lone goal in the first period.
The rematch, which took place at the same venue on September 18, witnessed the Tanzanian team sailing through to the second preliminary round with a 3-1 win to record a 4-1 aggregate win.
The Egyptian club is eager to enjoy a tremendous campaign in the second-tier of the continental tournaments at club level this season, having crashed out o the last four in the 2020/21 showpiece.
This season's CAF Confederation Cup is officially 2021/22 TotalEnergies CAF Confederation Cup for sponsorship reasons.
The showpiece is the 18th edition of Africa's secondary club football tournament organized by the Confederation of African Football (CAF), under the current CAF Confederation Cup title after the merger of the CAF Cup and African Cup Winners' Cup.
The winners of the 2020/21 CAF Confederation Cup got the right to play against the winners of the 2021/22 CAF Champions League in the 2022/23 CAF Super Cup.
Morocco's Raja Casablanca was the previous winner of the 2020/21 CAF Confederation Cup, beating JS Kabylie of Algeria in the final
The domestic cup winners from all 55 CAF member associations are eligible to participate in the showdown.
The third-placed club in the domestic league of the top 12 placed CAF member associations also qualify.
The competition is played into two phases A and B. In Phase A the matches of the Preliminary and the 1/32th rounds are played according to the knock-out system with ties broken via the away goals rule.
The 16 teams eliminated from the 1/16th finals of the CAF Champions League will automatically qualify to play the additional 1/16th finals round of the CAF Confederation Cup.
In Phase B the 16 teams which will qualify for the group matches from the additional 1/16th finals will be divided into four groups of four each.
Each team shall play six matches against the other three opponents one match home and one match away and points granted upon the 3-1-0 system.
The group winners and runners-up qualify to knock-out rounds which shall be played in two matches, home and away in three rounds (quarterfinals, semi-finals, and the finals).
In case of equality in the number of goals scored during the two matches, the team scoring the greatest number of away goals will be declared the winner.
If the number of goals scored on the away matches is equal, kicks from the penalty mark will be taken.