Yanga, who are currently positioned second with 59 points from 26 games, need victory in the only match of the day to take hold of the driver’s seat. The game will kick off at 4pm.
The Jangwani Street squad briefly occupied the top spot with a 3-0 win over Prisons at the same venue at the weekend.
Yanga, though, were knocked off the spot by Simba, who beat African Lyon 2-1 at the same venue the same weekend to register 62 points from 28 games.
Kagera Sugar, placed fourth with 47 points from 27 outings, will equally be keen on securing a win with a view to finishing in a much better position in the league.
The first phase match between the two teams, played at the Kaitaba Stadium last year, saw Yanga cruise to an emphatic 6-1 victory.
Two matches will be held on Friday, in which Simba SC will face Stand United of Shinyanga at the National Stadium while Azam FC will lock horns with Mwanza’s Toto African at the Azam Complex in Dar es Salaam.
Other matches will be played the following day, in which JKT Ruvu will entertain Majimaji at the Mkwakwani Stadium in Tanga, while Prisons will face Mtwara’s Ndanda at Sokoine Stadium in Mbeya.
On the same day, Mwadui FC from Shinyanga will be away to Mtibwa Sugar in the match to be played at Manungu Stadium in Mvomero, Morogoro while Mbeya City will travel to Dar es Salaam to face Yanga at the Uhuru Stadium.
African Lyon will welcome Ruvu Shooting at the Uhuru Stadium in Dar es Salaam on Sunday while Yanga will host Toto African from Mwanza at the National Stadium in Dar es Salaam on Tuesday next week.
The Mainland Premier League will come to an end on May 20 when all teams will throw their last cards.
On the day, Azam FC will welcome Kagera Sugar at the Azam Complex, Majimaji will host Mbeya City at the Majimaji Stadium in Songea while Simba SC will play Mwadui FC from Shinyanga at the National Stadium in Dar es Salaam.
Other matches will involve Mbao FC, who will entertain Yanga at the CCM Kirumba Stadium in Mwanza, Stand United who will host Ruvu Shooting at the Kambarage Stadium in Shinyanga, while Mtibwa Sugar will be at home to Toto Africans at the Manungu Stadium.
The day will also see African Lyon play away to Prisons at the Sokoine Stadium in Mbeya while Ndanda FC will be home hosting JKT Ruvu at the Nangwanda Sijaona Stadium in Mtwara.